Jimmy is a young man who was born without an immune system and has lived his life within a plastic bubble in his bedroom... who pines for the sweet caresses of girl-next-door Chloe. But when Chloe decides to marry her high school boyfriend, Jimmy – bubble suit and all – treks cross-country to stop her.
Jake Gyllenhaal
Jimmy Livingston
Swoosie Kurtz
Mrs. Livingston
Marley Shelton
Chloe
Danny Trejo
Slim
John Carroll Lynch
Mr. Livingston
Verne Troyer
Dr. Phreak
Dave Sheridan
Mark
Brian George
Pushpop
Patrick Cranshaw
Pappy / Pippy
Stephen Spinella
Chicken Man
Ever Carradine
Lisa, Mark's Sister
Geoffrey Arend
Flipper Boy
Beetlejuice
Li'l Zip
Matthew McGrory
Human Sasquatch
Bonnie Morgan
Rubber Woman
Jason Sklar
Shlomo
Randy Sklar
Dawn
Ping Wu
Emcee
Zach Galifianakis
Bus Stop Man
Boti Bliss
Cashier
Pablo Schreiber
Todd
Brian Gattas
Todd
Malik Toure
Todd
Leo Fitzpatrick
Todd
J.P. Coe
Todd
R.J. Durell
Todd
Brian Friedman
Todd
Arden Myrin
Lorraine
Merle Kennedy
Lorraine
Shulie Cowen
Lorraine
Alicia Gilley
Lorraine
Mitch Holleman
Jimmy, 4 Years Old
Alex Black
Jimmy, 8 Years Old
Tony Black
Jimmy, 10 Years Old
Robert Bailey Jr.
Neighborhood Boy
Oliver Kindred
Neighborhood Boy
Brandon de Paul
Neighborhood Boy
Steve Van Wormer
Mark's Friend
E.J. Callahan
Perris Townie
Charlie Dell
Perris Townie
Michael Loprete
Perris Townie
Charles Noland
Perris Townie
Emily Stewart
Perris Townie
Pattie Tierce
Perris Townie
Gary Bullock
Perris Sheriff
Susan Hawk
Perris Waitress
Steven Anthony Lawrence
Ice Cream Boy
Raja Fenske
Indian Boy
Cleo King
Minister
Robert LaSardo
Skinny Biker
Jorge Cottini
Big Biker
Mindie McCullum
Red Hot
Stacy Keibler
Working Girl
Fabio
Gil
Cyia Batten
Dancer (uncredited)
Bianca Butthole
Member of 'Betty Blowtorch' (uncredited)
Charles M. Kerper
Cult Member (uncredited)
Katie Lohmann
Cult Member (uncredited)
Daniel Mandehr
Casino Guy (uncredited)
Cal Thomas
Cult Member (uncredited)
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