Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.
Dwayne Johnson
Frank Wolff
Emily Blunt
Dr. Lily Houghton
Edgar Ramírez
Lope de Aguirre
Jack Whitehall
McGregor Houghton
Jesse Plemons
Prince Joachim
Paul Giamatti
Nilo Nemolato
Veronica Falcón
Trader Sam
Dani Rovira
Sancho
Quim Gutiérrez
Melchor
Andy Nyman
Sir James Hobbs-Coddington
Raphael Alejandro
Zaqueu
Simone Lockhart
Anna
Pedro Lopez
Chief
Sulem Calderon
Quila
Sebastian Blunt
Society Guard
Mark Ashworth
Society Member 1
Caroline Paige
Kid Tourist
James Quattrochi
Italian Tourist
Stephen Dunlevy
Middlepart
Philipp Maximilian
Axel
Romualdo Castillo
Animal Vendor
Pedro Haro
Bird Vendor
Christina Souza
Barmaid
Michael H. Cole
Bus Conductor
Hector Banos
Puka Michuna Warrior
Peter Luis Zimmerman
Puka Michuna Warrior
David Lengel
Boat Tourist
Justin Randell Brooke
Boat Tourist
Piper Collins
Boat Tourist
Keith Arthur Bolden
Boat Tourist
Tanya Wheelock
Boat Tourist (uncredited)
Robert Tinsley
London Guard (uncredited)
Victoria Blade
Boat Tourist
Brooke Jaye Taylor
Boat Tourist
Vince Pisani
Boat Tourist
Chip Steele
Boat Tourist
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