The Team Rocket leader, Giovanni, has found Mewtwo in a remote area of the Johto region. As Giovanni tries to re-capture Mewtwo, Ash and his friends are kidnapped by Domino, a new Team Rocket member, while trying to rescue Pikachu from Jessie and James. The Clone Pokemon are also captured and are then used as bait for Mewtwo. The situation then becomes a battle between the wills of Mewtwo and Giovanni; and Mewtwo also tries to discover if it and the clones have a purpose in life, even though they are products of science.
Rica Matsumoto
Satoshi (voice)
Ikue Otani
Pikachu (voice)
Mayumi Izuka
Kasumi (voice)
Satomi Korogi
Togepy (voice)
Yuji Ueda
Takeshi (voice)
Megumi Hayashibara
Musashi (voice)
Shin-ichiro Miki
Kojiro (voice)
Inuko Inuyama
Nyarth (voice)
Masachika Ichimura
Mewtwo (voice)
Hirotaka Suzuoki
Sakaki (voice)
Kotono Mitsuishi
Domino (voice)
Chinami Nishimura
Junsar (voice)
Unsho Ishizuka
Narrator (voice)
Aya Hisakawa
Luna Carson (voice)
Yumi Touma
Luka Carson (voice)
Rikiya Koyama
Penicillina (voice)
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