After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
Dan Castellaneta
Homer Simpson / Itchy / Barney / Abe Simpson / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice)
Julie Kavner
Marge Simpson / Selma Bouvier / Patty Bouvier (voice)
Nancy Cartwright
Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice)
Yeardley Smith
Lisa Simpson (voice)
Hank Azaria
Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice)
Harry Shearer
Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice)
Pamela Hayden
Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice)
Tress MacNeille
Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice)
Albert Brooks
Russ Cargill (voice)
Karl Wiedergott
Man / EPA Driver (voice)
Marcia Wallace
Edna Krabappel (voice)
Russi Taylor
Martin Prince (voice)
Maggie Roswell
Helen Lovejoy (voice)
Billie Joe Armstrong
Billie Joe Armstrong (voice)
Mike Dirnt
Mike Dirnt (voice)
Tré Cool
Tre Cool (voice)
Joe Mantegna
Fat Tony (voice)
Tom Hanks
Tom Hanks (voice)
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