FBI agent Neville Flynn boards a flight from Honolulu, Hawaii to Los Angeles, escorting a key witness to testify against a mob boss at an upcoming trial. An on-board assassin releases a crate full of hundreds of deadly venomous snakes in an attempt to eliminate the witness. Flynn and a host of frightened passengers and crew must band together to survive the slithery threat.
Samuel L. Jackson
Neville Flynn
Julianna Margulies
Claire Miller
Nathan Phillips
Sean Jones
Kenan Thompson
Troy
Rachel Blanchard
Mercedes
Flex Alexander
Three G's
Keith Dallas
Big Leroy
Sunny Mabrey
Tiffany
Lin Shaye
Grace
Elsa Pataky
Maria
Bruce James
Ken
Casey Dubois
Curtis
Gerard Plunkett
Paul
Terry Chen
Chen Leong
Emily Holmes
Ashley
Mark Houghton
John Sanders
David Koechner
Rick
Bobby Cannavale
Hank Harris
Yan-Kay Crystal Lowe
Autograph Girl
Todd Louiso
Dr. Steven Price
Kendall Cross
Driver
Samantha McLeod
Kelly
Ann Warn Pegg
Mrs. Bova
Taylor Kitsch
Kyle
Kevin McNulty
Emmett Bradley
Agam Darshi
Dell Girl
Lisa Marie Caruk
Ken's Girlfriend
Mi-Jung Lee
News Anchor
Byron Lawson
Edward Kim
Tom Butler
Captain Sam McKeon
Chris Taloa
Sprayer (uncredited)
David Neale
Navy Dad
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