Meet Spot, a clever little dog with big dreams of becoming a real boy. When Spot finds out that a crazy scientist can make his wish come true, he takes a cross-country trek with Leonard, his best friend and master, and their mom. However, Dr. Krank's experiments are a little less than perfect, and it will take Leonard and his pet pals to right this genetic wrong.
Nathan Lane
Spot Helperman / Scott Leadready II / Scott Manly-Manning (voice)
Kelsey Grammer
Dr. Ivan Krank (voice)
Shaun Fleming
Leonard Amadeus Helperman (voice)
Debra Jo Rupp
Mrs. Mary Lou Moira Angela Darling Helperman (voice)
David Ogden Stiers
Mr. Jolly (voice)
Jerry Stiller
Pretty Boy (voice)
Paul Reubens
Dennis (voice)
Megan Mullally
Adele (voice)
Wallace Shawn
Principal Crosby Strickler (voice)
Rob Paulsen
Ian Wazselewski (voice)
Jay Thomas
Barry Anger (voice)
Estelle Harris
Mrs. Boogin (voice)
Genie Francis
Marsha / Marcia (voice)
Anthony Geary
John / Juan (voice)
Rosalyn Landor
The Blue Fairy (voice)
Pamela Adlon
Trevor / Taylor / Tyler (voice)
Timothy Stack
Father (voice)
Emma Steinkellner
Little Girl (voice)
Ken Swofford
Officer White (voice)
Lauren Tom
Younghee (voice)
Mae Whitman
Leslie Dunkling (voice)
Kevin Michael Richardson
Conductor (voice)
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