An exploration of the United States of America's war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin's sheltered trophy wife must learn her husband's ruthless business after he is arrested, endangering her luxurious lifestyle.
Michael Douglas
Robert Wakefield
Benicio del Toro
Javier Rodriguez
Catherine Zeta-Jones
Helena Ayala
Erika Christensen
Caroline Wakefield
Don Cheadle
Montel Gordon
Jacob Vargas
Manolo Sanchez
Miguel Ferrer
Eduardo Ruiz
Luis Guzmán
Ray Castro
Topher Grace
Seth Abrahms
Tomas Milian
Gen. Arturo Salazar
Clifton Collins Jr.
Francisco Flores
Amy Irving
Barbara Wakefield
Dennis Quaid
Arnie Metzger
D.W. Moffett
Jeff Sheridan
Steven Bauer
Carlos Ayala
Albert Finney
Chief of Staff
James Brolin
General Ralph Landry
Enrique Murciano
DEA Agent - Trailer
Peter Riegert
Attorney Michael Adler
Benjamin Bratt
Juan Obregón
Yul Vazquez
Tigrillo / Obregón Assassin
Majandra Delfino
Vanessa
Alec Roberts
David Ayala
James Pickens Jr.
Prosecutor Ben Williams
Viola Davis
Social Worker
Andrew Chavez
Desert Truck Driver
Michael Saucedo
Desert Truck Driver
Jose Yenque
Salazar Soldier / The Torturer
Emilio Rivera
Salazar Soldier #2
Michael O'Neill
Lawyer Rodman
Russell G. Jones
Mark
Lorene Hetherington
State Capitol Reporter #1
Eric Collins
State Capitol Reporter #2
Beau Holden
DEA Agent - CalTrans
James Lew
DEA Agent - CalTrans
Don Snell
DEA Agent - Trailer
Gary Carlos Cervantes
DEA Agent - Trailer
Leticia Bombardier
Ruiz's Secretary
Gilbert Rosales
Van Passenger
Mike Watson
DEA Agent - Public Storage
Steve Tomaski
DEA Agent - Public Storage
Buck McDancer
DEA Agent - Public Storage
Brian Avery
DEA Agent - Public Storage
Corey Spears
F*****-up Bowman
Rena Sofer
Helena's Friend
Stacey Travis
Helena's Friend
Jennifer Barker
Helena's Friend
Dean Faulkner
Parking Valet
Daniella Kuhn
Tourist Woman
Brandon Keener
Tourist Man
Bill Weld
Governor Bill Weld
George Blumenthal
Partygoer #1
Stephen Dunham
Lobbyist
Don Nickles
Senator Don Nickles
Margaret Travolta
Economist
Harry Reid
Senator Harry Reid
Jeff Podolsky
Jeff Podolsky
Jewelle Bickford
Partygoer #2
Barbara Boxer
Senator Barbara Boxer
Orrin Hatch
Senator Orrin Hatch
Chuck Grassley
Senator Charles Grassley
Dave Hager
Partygoer #3
Tucker Smallwood
Partygoer #4
Marisol Padilla Sánchez
Ana Sanchez
Víctor Quintero
Salazar Soldier
Ramiro González
Salazar Soldier
Elaine Kagan
Judge Reed
John Slattery
ADA Dan Collier
Jimmy Ortega
Arrested Man in Apartment
Greg Boniface
Tackled Man #1
Thomas Rosales Jr.
Tackled Man #2
Rudy M. Camacho
Customs Official
Vonte Sweet
Dealer
Ed Breving
Hotel Deskman
Jack Conley
Agent Hughes
Eddie Velez
Agent Johnson
Craig N. Chretien
Director of EPIC
John Brown
Assistant Director of EPIC
Mike Siegel
DEA Representative
Stephen J. Rose
Marty
Kimber Fritz
Rehab Counselor
Harsh Nayyar
Witness #1
Mary Pat Gleason
Witness #2
Vincent M. Ward
Man on Street
Jsu Garcia
Pablo Obregón
Gregory Estevane
Polygraph Administrator
Alex Procopio
Polygraph Assistant
Rita Gomez
Mrs. Castro
Kaizaad Kotwal
Teacher
David Jensen
John
Jay Krymis
Waiter #1
Mike Malone
Waiter #2
René Pereyra
Doctor
Kymberly Newberry
Press Secretary
Carroll Schumacher
Ayala Security #1
Michael Showers
Meeting Leader
Salma Hayek Pinault
Rosario (uncredited)
Fred Anderson
TV Reporter (uncredited)
David Bickford
Stan (uncredited)
Adam Clark
FBI Agent (uncredited)
Chic Daniel
DEA Agent (uncredited)
Sonia Debreczeni
Reporter (uncredited)
Rod Fielder
Newspaper Photographer (uncredited)
Tony Guma
Detective (uncredited)
Valerie Hanna
Witness #3 (uncredited)
Dominic Koulianos
Reporter (uncredited)
Ambrit Millhouse
Cincinnati Hooker (uncredited)
David Pittinger
Cincinnati Police Officer (uncredited)
Christopher Rogers
Businessman (uncredited)
Leo Rogstad
Stand-In (uncredited)
Laurent Schwaar
Art Appraiser (uncredited)
Joey Sotello
DEA Agent / Attorney (uncredited)
William-Christopher Stephens
Drug Dealer (uncredited)
Clyde Tull
Cafe Patron (uncredited)
Fairly Tull
Cafe Patron (uncredited)
Jim Cody Williams
FBI Agent (uncredited)
Anthony Hawkins Woods
Junkie (uncredited)
William 'Shorty' Young
Court Room Participant (uncredited)
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