A masked villain wreaks mayhem on the city of Coolsville with a monster machine that creates real-life versions of Mystery Inc.'s former foes like The 10,000 Volt Ghost, The Cotton Candy Glob, The Skelemen and The Pterodactyl Ghost. Fred, Daphne, Shaggy, Velma and Scooby-Doo launch an investigation into the monster outbreak that leaves Shaggy and Scooby questioning their roles in Mystery Inc. Eager to prove their detective skills, the ever-ravenous duo comes up with a secret plan to solve the mystery all by themselves. Can the gang unravel their most challenging case?
Freddie Prinze Jr.
Fred
Sarah Michelle Gellar
Daphne
Matthew Lillard
Shaggy
Linda Cardellini
Velma
Neil Fanning
Scooby-Doo Voice / Tasmanian Devil (voice)
Seth Green
Patrick
Peter Boyle
Old Man Wickles
Tim Blake Nelson
Jacobo
Alicia Silverstone
Heather
Pat O'Brien
Pat O'Brien
Bill Meilen
Chauffeur
Zahf Paroo
Ned
Chris Gauthier
Daphne's Tattooed Fan #1
Peter New
Daphne's Tattooed Fan #2
Morgan Brayton
Mullet Nerdette #1
Lisa Ann Beley
Mullet Nerdette #2
Tara Fynn
Mullet Nerdette #3
Brandon Jay McLaren
Skater Dude #2
Aaron Ydenberg
Skater Dude #3
Joe MacLeod
Skater Dude #1
Bradley Gosnell
Kid on Bike #1
Calum Worthy
Kid on Bike #2
Brenna O'Brien
Buttercup Scout
Mark Burgess
Man in Suit
Kwesi Ameyaw
Man in Suit
Ted Kozma
Museum Guard
Darrell Lee-Izeard
Museum Guard
Stephen E. Miller
C.L. Magnus
Karin Konoval
Aggie Wilkins
Paul Jamieson
Scared Man
Andrew McIlroy
Investor
Colin Foo
Investor
Andrew Jackson
Man in Car
Nazanin Afshin-Jam
Shaggy Chick
Cascy Beddow
Young Shaggy
Emily Tennant
Young Daphne
Ryan Vrba
Young Fred
Lauren Kennedy
Young Velma
Jeff Tanner
Harry Lang
A.C. Peterson
Faux Ghost Patron
Dan Joffre
Faux Ghost Patron
Richard Dietl
Pickle Man/Faux Ghost Patron
Bill Mondy
Vomit Reporter
Kimani Ray Smith
Reporter #1
Catherine Lough Haggquist
Reporter #2
Ingrid Torrance
Reporter #3
Tiffani Timms
Reporter #4
Scott McNeil
Evil Masked Figure (voice)
Kevin Durand
Black Knight Ghost
C. Ernst Harth
Miner 49er
Christopher R. Sumpton
Zombie
Ruben Studdard
Ruben Studdard
Dee Bradley Baker
10,000 Volt Ghost / Zombie / Red Eye Skeleton (voice)
Bob Papenbrook
Black Knight (voice)
Michael Sorich
Tar Monster / Cotton Candy Glob (voice)
Terrence Stone
10,000 Volt Ghost (voice)
J.P. Manoux
Scooby Brainiac (voice)
Wally Wingert
Green-Eyed Skeleton (voice)
Michael Brown
Big Brovaz
Cherise Roberts
Big Brovaz
Nadia Shepherd
Big Brovaz
Dion Howell
Big Brovaz
Flawless
Big Brovaz
John-Paul Horsley
Big Brovaz
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