When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Jeff Goldblum
Professor Brody
Elizabeth Perkins
Mrs. Brody
Alexander Pollock
Scotty Brody
Miriam Margolyes
Sophie the Castle Maid
Tobey Maguire
Lou the Beagle (voice)
Alec Baldwin
Butch (voice)
Sean Hayes
Mr. Tinkles (voice)
Susan Sarandon
Ivy (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
Jon Lovitz
Calico (voice)
Charlton Heston
The Mastiff (voice)
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