When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Jeff Goldblum
Professor Brody
Elizabeth Perkins
Mrs. Brody
Alexander Pollock
Scotty Brody
Miriam Margolyes
Sophie the Castle Maid
Tobey Maguire
Lou the Beagle (voice)
Alec Baldwin
Butch (voice)
Sean Hayes
Mr. Tinkles (voice)
Susan Sarandon
Ivy (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
Jon Lovitz
Calico (voice)
Charlton Heston
The Mastiff (voice)
Billy West
Ninja Cat #1 (voice)
John Michael Higgins
Ginger Kitten (voice)
Richard Steven Horvitz
Puppy in Barn (voice)
Frank Welker
Buddy (voice)
Frank C. Turner
The Farmer
Lauren K. Robek
Pie Mom (as Kirsten Robek)
Mar Andersons
Guard at Gate
Gillian Barber
Factory Receptionist
Carol Ann Susi
Sophie's Sister
Randi Kaplan
Sophie's Sister
Mary Bogue
Sophie's Sister
Alvin Sanders
Mason Employee
Mark Schooley
Mason Employee
Babe Dolan
Wife Passenger
Charles Andre
Truck Driver
Peggy Logan
Nurse
Alicia Michelle
Jogger
Pamela Perry
Yorkie Dog Owner
Victor Wilson
Doberman Drill Sergeant (voice)
Salome Jens
Collie at HQ (voice)
Danny Mann
Ninja Cat (voice)
Billy West
Ninja Cat (voice)
Paul Pape
Wolf Blitzer (voice)
Myron Natwick
Mr. Mason
Doris Chillcott
Mrs. Calvert
Frank Meschkuleit
Additional Performances (puppeteer)
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